|
Colorectal Neoplasms
|
0.700 |
ModifyingMutation
|
group |
RGD |
Green tea polyphenols inhibit colorectal aberrant crypt foci (ACF) formation and prevent oncogenic changes in dysplastic ACF in azoxymethane-treated F344 rats.
|
17893236 |
2008 |
|
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
BEFREE |
However, about 10% of colorectal tumors also exhibit increased CTNNB1 mRNA.
|
27758879 |
2016 |
|
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
BEFREE |
MUC5AC/β-catenin expression and KRAS gene alteration in laterally spreading colorectal tumors.
|
23112547 |
2012 |
|
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
LHGDN |
Regulation of AKT1 expression by beta-catenin/Tcf/Lef signaling in colorectal cancer cells.
|
15888491 |
2005 |
|
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
BEFREE |
MUC13 promotes the development of colitis-associated colorectal tumors via β-catenin activity.
|
31427737 |
2019 |
|
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
LHGDN |
Mutations in APC, CTNNB1 and K-ras genes and expression of hMLH1 in sporadic colorectal carcinomas from the Netherlands Cohort Study.
|
16356174 |
2005 |
|
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
BEFREE |
Finally, we show that YAP expression is elevated in the majority of a panel of primary human colorectal tumors compared with its expression in uninvolved colonic mucosa, and that YAP and β-catenin localize to the nuclear compartment of tumor cells.
|
22337891 |
2012 |
|
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
BEFREE |
JMJD2D interacts with β-catenin to activate transcription of its target genes and promote CRC cell proliferation, migration, and invasion, as well as formation of colorectal tumors in mice.
|
30472235 |
2019 |
|
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
LHGDN |
Nuclear beta-catenin expression is closely related to ulcerative growth of colorectal carcinoma.
|
11953860 |
2002 |
|
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
BEFREE |
Increased triplex DNA-binding activity in vitro correlates with lymph node disease, metastasis, and reduced overall survival in colorectal cancer, and increased U2AF65 expression is associated with total and truncated beta-catenin expression in high-stage colorectal tumors.
|
22682314 |
2012 |
|
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
LHGDN |
Relation of E-cadherin and beta-catenin expression to pit pattern in colorectal cancer.
|
15289833 |
2004 |
|
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
LHGDN |
Positive KL-6 mucin expression combined with decreased membranous beta-catenin expression indicates worse prognosis in colorectal carcinoma.
|
18949395 |
2008 |
|
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
BEFREE |
The observation that TNFRSF19 is a β-catenin target gene and TNFRSF19 receptor molecules activate NF-κB signaling shows that β-catenin regulates NF-κB activity via TNFRSF19, suggesting that TNFRSF19 may contribute to the development of colorectal tumors with deregulated β-catenin activity.
|
24623448 |
2014 |
|
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
LHGDN |
Elevated protein expression of cyclin D1 and Fra-1 but decreased expression of c-Myc in human colorectal adenocarcinomas overexpressing beta-catenin.
|
12209953 |
2002 |
|
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
BEFREE |
Interestingly, the levels of Tbeta-4 mRNA, beta-catenin, c-Myc, and MMP-7 in metastatic liver lesions were relatively higher, whereas the levels of E-cadherin and Fas were significantly lower than those in the matched primary colorectal tumors.
|
15235586 |
2004 |
|
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
BEFREE |
These results suggest that although there may be a number of mechanisms responsible for changes in beta-catenin expression in colorectal tumors, dysfunction of APC may be the major cause of this phenomenon.
|
11956815 |
2002 |
|
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
BEFREE |
Inverse correlation of the up-regulation of FZD10 expression and the activation of beta-catenin in synchronous colorectal tumors.
|
19134005 |
2009 |
|
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
BEFREE |
The β-catenin-TCF transcription complex activates both the physiological expression of Wnt target genes in the normal intestinal epithelium and their aberrantly increased expression in colorectal tumors.
|
28708826 |
2017 |
|
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
LHGDN |
Nuclear beta-catenin expression as a prognostic factor in advanced colorectal carcinoma.
|
18609711 |
2008 |
|
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
LHGDN |
Activator protein 2alpha associates with adenomatous polyposis coli/beta-catenin and Inhibits beta-catenin/T-cell factor transcriptional activity in colorectal cancer cells.
|
15331612 |
2004 |
|
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
LHGDN |
Pin1 overexpression in colorectal cancer and its correlation with aberrant beta-catenin expression.
|
16124054 |
2005 |
|
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
LHGDN |
Expression level of Wnt signaling components possibly influences the biological behavior of colorectal cancer in different age groups.
|
15126105 |
2004 |
|
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
BEFREE |
TCF-4 and beta-catenin form a transcription complex, which is important for both maintenance of normal epithelium and development of colorectal tumors.
|
12036905 |
2002 |
|
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
LHGDN |
Cell-cycle and apoptosis regulators (p16INK4A, p21CIP1, beta-catenin, survivin, and hTERT) and morphometry-defined MPECs predict metachronous cancer development in colorectal adenoma patients.
|
17641414 |
2007 |
|
Colorectal Neoplasms
|
0.700 |
AlteredExpression
|
group |
BEFREE |
Collectively, our data indicate that KDM4B overexpression supports β-catenin mediated gene transcription and thereby contributes to the genesis of colorectal tumors.
|
24481461 |
2014 |